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M94A2397.TXT
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1994-10-25
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Document 2397
DOCN M94A2397
TI HIV infection in women: a eight year longitudinal observational study.
DT 9412
AU Laynez F; Diez F; Collado A; Yelamos F; Fernandez P; Hospital
Torrecardenas, Almeria, Spain.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):313 (abstract no. PC0184). Unique
Identifier : AIDSLINE ICA10/94370178
AB OBJECTIVE: To study the epidemiology, clinical characteristics and
evolution in a cohort of HIV-infected women in the South of Spain.
METHODS: A observational study of 242 HIV+ women from their first study
to the last clinical control or death, between 1/86-12/93. Kaplan Meier
and logrank tests were used for survival analysis. RESULTS: Median age
was 30 years. HIV risks included IDU in 64%, heterosexual contact in
32%, transfusion in 3% and unknown in 1%. The proportion of
heterosexually infected patients showed an increase from 16% in
1986-1987 to 50% in 1992-1993. Only 143 patients (59%) are periodically
controlled. At entry 31 (29%) had more than 500 CD4/mm, 45 (42%O had
between 200-500 CD4/mm, 17 (16%) between 50-200 CD4/mm and 13 (12%) less
than 50 CD4/mm. Of the 33 (23%) women with AIDS, the inicial AIDS
defining conditions were Candida esophagitis (8), PCP (8), caquexia (6),
disseminated tuberculosis (5), cerebral toxoplasmosis (3) and CMV
iotinitis, Kaposi sarcoma and lymphoma (1u each). 16 (11%) women have
died. The median survival time was 5.5 years from the first clinical
control and 20 months from AIDS diagnosis. CD4 count at entry was the
most powerful marker of survival. No other survival differences were
detected based on risk factor or AIDS-defining diagnosis. Overall
survival was similar to that of men. CONCLUSIONS: 1) In this area, IDU
is the first HIV-risk behavior in women and heterosexual transmission is
increasing very quickly. 2) Only 59% of HIV-infected women have periodic
follow up. 3) CD4 count at entry is the stronger marker of evolution.
DE Acquired Immunodeficiency Syndrome/DIAGNOSIS/MORTALITY Adult
AIDS-Related Opportunistic Infections/EPIDEMIOLOGY Cohort Studies
Female Human *HIV Infections/DIAGNOSIS/EPIDEMIOLOGY HIV
Seropositivity Risk Factors Sex Behavior Spain/EPIDEMIOLOGY Survival
Rate MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).